Epstein-Barr Virus in Systemic Autoimmune Diseases
نویسندگان
چکیده
منابع مشابه
Epstein-Barr Virus in Systemic Autoimmune Diseases
Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development. The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs. Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development. EBV causes a persi...
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The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of autoimmune disease, with Epstein-Barr virus (EBV) being implicated in several autoimmune disorders. EBV is appealing in the pathogenesis of autoimmune disease, due to its high p...
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During infectious mononucleosis, IgM autoantibodies are generated to a protein, p542, which contains a glycine-rich 28-mer epitope cross-reactive with the Epstein-Barr nuclear antigen-1 through Epstein-Barr nuclear antigen-l's glycine/ alanine repeat. In normal individuals it is uncommon to find IgG anti-p542, but among patients with progressive systemic sclerosis, systemic lupus erythematosus,...
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Epstein-Barr is a member of the herpesvirus family that infects more than 90% of the worlds population. Although primary infection typically occurs within the first few years of life or in adolescence and is generally asymptomatic or results in infectious mononucleosis respectively, in some cases the virus is implicated with the development of a large spectrum of gastrointestinal malignant and...
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ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2013
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2013/535738